Niacinamide Face serum reduces inflammation, which may help ease redness from eczema, acne, and other inflammatory skin conditions. Minimizes pore appearance. Keeping skin smooth and moisturized may have a secondary benefit a natural reduction in pore size over time. It's best to apply them after cleansing and toning and before oil-based serums or moisturizers. This way, you ensure the highest possible absorption and effectiveness.